F5 and NVIDIA to meet the needs of accelerated computing and AI
F5 has announced new capabilities for F5 BIG-IP Next for Kubernetes accelerated with NVIDIA BlueField-3 DPUs and the NVIDIA DOCA software framework, underscored by customer Sesterce's validation deployment.
Sesterce is a leading European operator specialising in next-generation infrastructures and sovereign AI, designed to meet the needs of accelerated computing and artificial intelligence.
Extending the F5 Application Delivery and Security Platform, BIG-IP Next for Kubernetes running natively on NVIDIA BlueField-3 DPUs delivers high-performance traffic management and security for large-scale AI infrastructure, unlocking greater efficiency, control, and performance for AI applications. In tandem with the compelling performance advantages announced along with general availability earlier this year, Sesterce has successfully completed validation of the F5 and NVIDIA solution across a number of key capabilities, including the following areas:
– Enhanced performance, multi-tenancy, and security to meet cloud-grade expectations, initially showing a 20% improvement in GPU utilisation.
– Integration with NVIDIA Dynamo and KV Cache Manager to reduce latency for the reasoning of large language model (LLM) inference systems and optimisation of GPUs and memory resources.
– Smart LLM routing on BlueField DPUs, running effectively with NVIDIA NIM microservices for workloads requiring multiple models, providing customers the best of all available models.
– Scaling and securing Model Context Protocol (MCP) including reverse proxy capabilities and protections for more scalable and secure LLMs, enabling customers to swiftly and safely utilise the power of MCP servers.
– Powerful data programmability with robust F5 iRules capabilities, allowing rapid customisation to support AI applications and evolving security requirements.
'Integration between F5 and NVIDIA was enticing even before we conducted any tests', said Youssef El Manssouri, CEO and Co-Founder at Sesterce. 'Our results underline the benefits of F5's dynamic load balancing with high-volume Kubernetes ingress and egress in AI environments. This approach empowers us to more efficiently distribute traffic and optimise the use of our GPUs while allowing us to bring additional and unique value to our customers. We are pleased to see F5's support for a growing number of NVIDIA use cases, including enhanced multi-tenancy, and we look forward to additional innovation between the companies in supporting next-generation AI infrastructure'.
Highlights of new solution capabilities include:
LLM Routing and Dynamic Load Balancing with BIG-IP Next for Kubernetes
With this collaborative solution, simple AI-related tasks can be routed to less expensive, lightweight LLMs in supporting generative AI while reserving advanced models for complex queries. This level of customisable intelligence also enables routing functions to leverage domain-specific LLMs, improving output quality and significantly enhancing customer experiences. F5's advanced traffic management ensures queries are sent to the most suitable LLM, lowering latency and improving time to first token.
'Enterprises are increasingly deploying multiple LLMs to power advanced AI experiences—but routing and classifying LLM traffic can be compute-heavy, degrading performance and user experience', said Kunal Anand, Chief Innovation Officer at F5. 'By programming routing logic directly on NVIDIA BlueField-3 DPUs, F5 BIG-IP Next for Kubernetes is the most efficient approach for delivering and securing LLM traffic. This is just the beginning. Our platform unlocks new possibilities for AI infrastructure, and we're excited to deepen co-innovation with NVIDIA as enterprise AI continues to scale'.
Optimizing GPUs for Distributed AI Inference at Scale with NVIDIA Dynamo and KV Cache Integration
Earlier this year, NVIDIA Dynamo was introduced, providing a supplementary framework for deploying generative AI and reasoning models in large-scale distributed environments. NVIDIA Dynamo streamlines the complexity of running AI inference in distributed environments by orchestrating tasks like scheduling, routing, and memory management to ensure seamless operation under dynamic workloads. Offloading specific operations from CPUs to BlueField DPUs is one of the core benefits of the combined F5 and NVIDIA solution. With F5, the Dynamo KV Cache Manager feature can intelligently route requests based on capacity, using Key-Value (KV) caching to accelerate generative AI use cases by speeding up processes based on retaining information from previous operations (rather than requiring resource-intensive recomputation). From an infrastructure perspective, organisations storing and reusing KV cache data can do so at a fraction of the cost of using GPU memory for this purpose.
'BIG-IP Next for Kubernetes accelerated with NVIDIA BlueField-3 DPUs gives enterprises and service providers a single point of control for efficiently routing traffic to AI factories to optimize GPU efficiency and to accelerate AI traffic for data ingestion, model training, inference, RAG, and agentic AI,' said Ash Bhalgat, Senior Director of AI Networking and Security Solutions, Ecosystem and Marketing at NVIDIA. 'In addition, F5's support for multi-tenancy and enhanced programmability with iRules continue to provide a platform that is well-suited for continued integration and feature additions such as support for NVIDIA Dynamo Distributed KV Cache Manager'.
Improved Protection for MCP Servers with F5 and NVIDIA
Model Context Protocol (MCP) is an open protocol developed by Anthropic that standardizes how applications provide context to LLMs. Deploying the combined F5 and NVIDIA solution in front of MCP servers allows F5 technology to serve as a reverse proxy, bolstering security capabilities for MCP solutions and the LLMs they support. In addition, the full data programmability enabled by F5 iRules promotes rapid adaptation and resilience for fast-evolving AI protocol requirements, as well as additional protection against emerging cybersecurity risks.
'Organisations implementing agentic AI are increasingly relying on MCP deployments to improve the security and performance of LLMs', said Greg Schoeny, SVP, Global Service Provider at World Wide Technology. 'By bringing advanced traffic management and security to extensive Kubernetes environments, F5 and NVIDIA are delivering integrated AI feature sets—along with programmability and automation capabilities—that we aren't seeing elsewhere in the industry right now'.
F5 BIG-IP Next for Kubernetes deployed on NVIDIA BlueField-3 DPUs is generally available now. For additional technology details and deployment benefits, go to www.f5.com and visit the companies at NVIDIA GTC Paris, part of this week's VivaTech 2025 event. Further details can also be found in a companion blog from F5.
Image Credit: F5
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Because Supercharged wasn't just about what was said on stage, it was about the ideas that emerged offstage. The ones shaping what's next. Curated Highlights To better support editors and journalists covering distinct news verticals, we've distilled key moments from Supercharged 2025 into three thematic categories: Business & Technology, Lifestyle, and UAE News (more information for each can be found in the corresponding sections above or shared by our agency). Business & Technology Supercharged 2025 spotlighted G42's evolution into a global AI systems architect, with fireside chat appearances by Microsoft's Brad Smith and OpenAI's Sam Altman, reinforcing strategic alignment. Central to the event was G42's vision for the 'Intelligence Grid,' a distributed network of AI models, data centers, and compute infrastructure already taking shape through initiatives like Stargate UAE and the 5GW UAE–U.S. AI Campus. The summit also featured breakthroughs from AI-native firm Analog and G42's new Intelligence Grid interactive and immersive experience. UAE News High-level UAE leadership played a central role at the event, with H.E. Mansoor Al Mansoori (DoH), H.E. Mohamed Al Kuwaiti (Cybersecurity Council), and H.E. Eng. Salem Al Qubaisi (UAE Space Agency) all contributing insights. The program demonstrated Abu Dhabi's commitment to global leadership in health, space, cybersecurity, and responsible AI. Additionally, H.E. Ibrahim Al Jallaf, Executive Director of Digital Health, DoH – Abu Dhabi and H.E. Ahmed Al Shamsi, CEO of Emirates Foundation, attended dedicated sessions. Lifestyle Beyond AI, Supercharged 2025 offered a fully immersive cultural and sensory experience with a curated 'Global Food Grid' dining journey, live performances by David Chesky, and a trailer for the Bee:wild documentary, which features Angelina Jolie and Ellie Goulding. Now part of Re:wild, Leonardo DiCaprio's conservation NGO, the initiative highlights global efforts to protect pollinators and biodiversity. It was a celebration of creativity, sustainability, and tech-driven storytelling. Full Days Agenda Time Agenda Item Session Title Speakers 08:00 09:00 ARRIVAL OF GUESTS 09:00 09:10 Intro & Welcome 'Welcome to Supercharged' Faheem Ahamed, Group CMO, G42 09:10 10:00 Keynote 'G42 Journey and Future of Industry ' Peng Xiao, Group CEO, G42 10:00 10:30 Fireside Chat ' The Intelligence Grid: Lives Lifted Everywhere' Peng Xiao, Group CEO, G42, Brad Smith, President and Vice Chairman, Microsoft 10:35 11:30 BREAK 11:30 12:00 Panel 'The AI Energy Nexus: Long Live Electric Dreams' Moderated by Magdalena Konig, General Counsel, AIQ Hassan Alnaqbi, CEO, Khazna Chris Midgley, SVP, Energy Intelligence & Outlooks, ADNOC Andy Hock, Chief Product & Strategy Officer, Cerebras Systems 12:00 12:05 Opening Remarks 'The Intelligence to Live Longer, Better' H.E. Mansoor Ibrahim Al Mansoori, Chairman, Department of Health - Abu Dhabi 12:05 12:45 Panel 'The Leap to Longevity: Forever Healthy' Moderated by Amandeep Bhangu, Presenter & Moderator Voice Media London H.E. Ibrahim Al Jallaf, Executive Director of Digital Health, Department of Health - Abu Dhabi Dr. Tiffany Vora, Expert & Singularity Fellow in Biotechnology, Singularity University and Non-resident Senior Fellow at the GeoTech Center for the Atlantic Council. PhD. Georges-Pascal Haber, CEO, Cleveland Clinic Abu Dhabi Dimitris Moulavasilis, CEO, M42 12:45 13:15 Panel 'Intelligence From Space: The New Frontiers on Earth' Moderated by Talal M. Al Kaissi, EVP, Chief Government Affairs & Partnerships Officer - Core42 & Group Chief Global Affairs Officer, G42 Karim Sabbagh, MD, Space42 H.E. Eng. Salem Butti Al Qubaisi, Director General, UAE Space Agency Greg Wyler, Founder, CEO & Chief Architect, E-Space 13:15 15:05 LUNCH BREAK 15:05 15:45 Panel 'AI-Native Nations: Smarter Lives Unlocked' Moderated by Brian Lott, Group Chief Communications Officer, Mubadala Opening Remarks by H.E. Dr. Mohamed Hamad Al Kuwaiti, Head of the UAE Cybersecurity Council Thomas Pramotedham, CEO, Presight Kiril Evtimov, Group CTO, G42 & CEO, Core 42 Rod Solaimani, Middle East Policy & Partnerships Lead, OpenAI 15:45 16:25 Panel 'Responsible Intelligence: Igniting The Future' Moderated Faheem Ahamed, Group CMO, G42 H.E. Ahmed Al Shamsi, CEO, Emirates Foundation Andrew Jackson, Group Chief AI Officer Baroness Joanna Shields, Founder and CEO of Precognition Natasha Crampton, VP, Chief Responsible AI Officer, Microsoft 16:25 16:30 Bee:Wild documentary presentation Faheem Ahamed 16:30 17:30 BREAK 17:30 18:00 Keynote 'The AI-Physical AI Revolution: More Than Humans' Alex Kipman, CEO, Analog 18:00 18:30 Fireside Chat 'AI First Organizations: Augmented Thought Leadership' Maymee Kurian, Group Chief Human Capital & Culture Officer, G42 Josh Bersin, Founder and CEO, The Josh Bersin Company 18:30 19:00 Closing Remarks Peng Xiao, Group CEO, G42 Sam Altman, Founder and CEO, OpenAI 19:00 21:00 DINNER Across breakfast, lunch, dinner, and everything in between, Supercharged guests will experience the Global Food Grid - a curated culinary journey celebrating the richness of global traditions. Guests can choose between four immersive dining paths, each inspired by a different region of the world: the Middle East and India, the Americas, Europe, and Asia. Performance by acclaimed composer David Chesky and his Jazz Trio band 21:00 00:00 EVENING ENTERTAINMENT 9:00 PM - 9:45 PM Raphy J, an Amsterdam-born open format DJ and music producer, will bring his global sound to the stage. With a career spanning London, New York, LA, and now Dubai, Raphy J is known for his genre-spanning performances—seamlessly mixing Pop, R&B, Afrobeats, House, Latin, Arabic, and Hindi music. His sets have lit up stages at venues like Expo 2020, Time Out Market, and the Museum of the Future. ABOUT G42 G42 is a technology holding group and a global leader in creating visionary artificial intelligence for a better tomorrow. Born in Abu Dhabi and operating worldwide, G42 champions AI as a powerful force for good across industries. From molecular biology to space exploration and everything in between, G42 realizes exponential possibilities today. Media contact TrailRunner International – G42@
Zawya
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Additionally, AI-powered chatbots and virtual health assistants are streamlining telemedicine services, providing preliminary diagnoses and scheduling appointments, thus improving access to care. AI's Role in Medical Research Beyond frontline care, GenAI is turbocharging work in the field of medical research. Earlier this year, a researcher at Imperial College London used an AI tool developed by Google to investigate why certain bacteria are resistant to antibiotics. In just 48 hours, the tool proposed four viable hypotheses, whereas it had taken scientists over a decade to finalise just a single hypothesis manually. The result was so astonishing that the original researcher initially suspected the AI had accessed unpublished work on his personal computer, which was proven not to have been the case. These breakthroughs are being made possible thanks to the high-performance computing systems behind increasingly powerful AI models. At Lenovo, we are proud to partner with the Broad Institute on genome analysis, helping researchers accelerate one of the most data-intensive tasks in science. The Lenovo Genomics Optimization and Scalability Tool (GOAST) reduces the time needed to analyse a whole human genome from over 100 hours to just 47 minutes. Other organizations are also harnessing advanced AI and computing tools to push the boundaries of healthcare. Hungarian company 3DHISTECH, for example, uses Lenovo's AMD Threadripper-powered ThinkStation P620 workstations to build detailed 3D virtual models of human and non-human tissue. These models can zoom in to the level of individual chromosomes, enabling new frontiers in digital pathology. Their systems are used by institutions around the world, including Harvard Medical School, Novartis, and the Wuhan Institute of Virology. Notably, a 3DHISTECH system played a pivotal role in diagnosing the first COVID-19 patient in China, demonstrating how AI-enabled technology can impact global health crises. The Human Element Remains Crucial While AI offers compelling advantages, it's important to remember that technology alone isn't the answer. The human touch in healthcare remains indispensable. Healthcare providers must ensure transparency in their AI implementations and address data quality issues to fully reap the benefits of AI. By doing so, they can enhance patient care, reduce burnout among medical staff, and drive groundbreaking research, all without sacrificing the trust and comfort of those they serve. In conclusion, the healthcare industry stands at the brink of an AI-driven revolution. With thoughtful implementation and a focus on maintaining trust, AI has the potential to transform healthcare for the better. The journey won't be without its challenges, but the rewards promise to be well worth the effort. By Ashley Woodbridge, CTO, Lenovo, META
